Compound Screening​

RosetteArray platforms are engineered for high-throughput developmental neurotoxicity (DNT) screening. If you have a compound or drug that you would like screened for DNT, Neurosetta can run your agent through our assays in-house using our standard forebrain or spinal cord progenitors. We will run dose-response studies to quantify your agent’s impact on cell viability, cell proliferation, neural differentiation, and rosette/neural tube morphogenesis. Neurosetta will provide a report of this data to enable an informed estimation of the compound’s human DNT risk.

Patient-Specific Disease Modeling​

RosetteArray technology is ideal for modeling a variety of neurodevelopmental disorders (e.g., neural tube defects, Autism spectrum disorder). At Neurosetta, we can assay a patient-derived or a genetically modified hPSC line for a neurodevelopmental disorder phenotype. We will arrange to have your cells shipped to us, conduct a customized RosetteArray assay for you with appropriate controls, and provide you with quantitative relative odds ratios for each cell line’s predisposition to abnormal neurodevelopment.

Our patient-specific modeling service can also be combined with our compound screening service to conduct precision medicine screens which may efficiently identify disease-specific therapeutic candidates to prevent or potentially treat neurodevelopmental disorders.

RosetteArray and Custom Micropatterned Well Plates

Neurosetta manufactures 96-, 24-, and 6-well RosetteArray plates for purchase. Also, we can manufacture micropatterned well plates with arrays of cell-adhesive features matching your geometries and dimensions of interest. All custom plates will be built using the same highly stable surface chemistry that makes RosetteArray plates capable of extended micropatterned culture.